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We are the only scientifically validated genetic prediction technology for consumers. Read more

OmicsEdge Capabilities

Clinically Validated Polygenic Risk Scores

for Precision Health

Our ancestry-informed polygenic risk scoring empowers our partners to provide highly accurate genetics predispositions for over 600 health conditions.
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Cutting-edge genetic imputation models

Leverage our state-of-the-art genetic imputation algorithm, capable of accurately imputing over 200 million genetic variants with 99.99% precision. This deep variant analysis allows us to incorporate a significantly larger number of variants in our Polygenic Risk Scores, empowering your company with the comprehensive investigative and diagnostic capabilities of Whole Genome Sequencing—at a fraction of the cost.

Partner with us to enhance your offerings with our robust, validated Polygenic Risk Scoring services.

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Read the OmicsEdge Whitepaper: Polygenic Risk Scores Validation

How It Works

Provide Genetic Data

Upload raw genetic data to our platform or take advantage of our CLIA/CAP certified DNA test kit. OmicsEdge will run the data through our industry-leading imputation algorithm to impute over 200 million genetic variants for more accurate polygenic testing.

Submit Genetic Data

Easily upload your customers’ raw genetic data to our platform, or utilize our CLIA/CAP certified DNA test kits. OmicsEdge applies our advanced imputation algorithm to expand genetic coverage to up to 200 million variants, ensuring the most precise polygenic risk assessments available.

Generate Tailored PRS Reports

Select from over 1450+ report options to create comprehensive polygenic risk scores. Access these scores seamlessly via the OmicsEdge API, or receive fully customizable, whitelabeled DNA Health Reports complete with personalized health insights and recommendations.

View sample PRS report
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How We Calculate Polygenic Risk Scores

GWASs look for genetic differences between disease cases and healthy controls. Each GWAS examines millions of variants. If variants are much more or less common in the case group they may be associated with the disease. Each variant’s effect size is an estimate of its contribution to disease risk. Aggregating the effects of the disease-associated variants yields PRSs [R, R].

Polygenic Risk Scores (PRS) sum up the impacts of many inherited variants on the risk of developing a specific disease. They can identify high-risk individuals to target for early therapeutic intervention [R]. Most PRS models include thousands of variants with small effects on disease risk. These variants are identified by Genome-Wide Association Studies (GWAS).
PRS models built from larger or even multiple GWASs tend to be more predictive. We generate and test a great number of PRS models. Once we build a PRS model, we check the risk predictions in another validation dataset. These datasets include genetic information and case-control status in a new independent group.
To check that our PRS are accurate in diverse patient populations, we create models for different ancestries. We then test their performance in multiple populations. We also apply techniques to decrease the impact of biased associations. These practices significantly increase the effectiveness of our PRS reports in clinical settings.

Custom Reports

Go beyond off-the-shelf solutions with our bespoke polygenic risk scoring reports, tailored precisely to your needs. Define the health condition, and we’ll leverage the latest in genetic research and data analysis to generate a custom report exclusively for you. Choose from original genome-wide association studies, expertly curated summaries of existing models, or a combination of approaches. Gain a deeper understanding of your target market and develop truly personalized health solutions with our unique, data-driven insights.
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The OmicsEdge Advantage

  • World's most accurate polygenic risk scores
  • World's largest health recommendations engine
  • AI-driven patent pending technology
  • Algorithms validated on datasets of 2M+ people
  • Ancestry-adjusted risk scores for unmatched accuracy
  • Built by a team of 60+ scientists and engineers
  • Trusted by the thousand of doctors and leading health tech companies.
  • HIPAA & GDPR compliant
  • Validated & peer-reviewed in 6 scientific papers
View Sample PRS Report
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Read our research on polygenic risk scoring

See Everything OmicsEdge Has to Offer

Discover our full suite of health reports and features in one comprehensive guide.
Our Reports & Features Summary shows all the reports, tools, and insights you can get with OmicsEdge.

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